Preparing for his U.S. Open title defense, the 20-year-old Wimbledon champion ran his match winning streak to 14, dating to his Queen’s title run. He leads the tour with six victories and 49 match victories against just four losses.
Medvedev, the 2021 winner in Toronto who has five tour victories this year, will face Alex de Minaur of Australia. De Minaur topped eighth-seeded Taylor Fritz of the United States 7-6 (7), 4-6, 6-1.
Spain’s Alejandro Davidovich Fokina upset third-seeded Casper Ruud of Norway 7-6 (4), 4-6, 7-6 (4). Fokina set up a match with American Mackenzie McDonald, a 6-3, 6-3 winner over 32-year-old Canadian Milos Raonic.
Andy Murray, the 36-year-old Scot who won the event in 2009, 2010 and 2015, faced seventh-seeded Jannik Sinner of Italy in a late match. The winner will play fellow 36-year-old Gael Monfils of France, a 6-4, 6-4 winner over Australia’s Aleksandar Vukic.
Rain suspended play for just over an hour early in the afternoon.